Dr. Thibault Mesplède
McGill University AIDS CentreView Bio
The LAGHDA Study is a retrospective pilot study that will measure the genetic evolution of HIV DNA in adults with controlled viral loads and how this evolution is affected by different types of antiretroviral regimens.
HIV that is successfully and continually suppressed by antiretroviral therapy (ART) can continue to evolve and mutate within viral reservoirs and immune cells throughout the body. Integrase inhibitors are a class of ART drugs that include raltegravir, elvitegravir, dolutegravir, and bictegravir. Integrase inhibitor-based ART regimens are effective at suppressing HIV replication; however, these drugs may also be more effective at preventing the evolution of HIV DNA, compared to other types of treatments. Understanding which treatments are more effective at limiting viral evolution is valuable to clinicians and people living with HIV by helping to inform treatment decisions and importantly, may lead to clues about the mechanisms associated with HIV replication and persistence.
This study is retrospective, meaning it will analyze and interpret existing samples from people who previously consented to have their data used for future studies. Historical samples for a 12-month period from three different groups of people will be used: samples from 10 people who were successfully treated with dolutegravir, from 10 who were treated with elvitegravir, and 10 with a non-integrase inhibitor ART. Through DNA sequencing, researchers will compare the extent of the genetic evolution of the viruses collected in each group of people and determine which ART regimen was most effective for this purpose.
If you would like more information on this clinical study, please contact the principal investigator.
Jewish General Hospital 3755 Ch. Côte-Ste-Catherine Montréal, QC H3T 1E2