About The Study

CTN 327 will explore the effects of COVID-19 on people living with HIV or both HIV and hepatitis C virus (HCV). The study will look at the experiences of people during the pandemic and their satisfaction with virtual care. It will also test whether participants have had COVID-19 (with or without symptoms) and catalogue the severity of the disease.

About The Disease

COVID-19 has had significant effects on marginalized communities, including people living with HIV. People living with HIV, or both HIV and HCV, have faced unique challenges and disruptions related to the pandemic. While these clinical, social, and economic effects have been studied in some populations, they have not been adequately studied in Canadians living with HIV.

Study Approach

CTN 327 is a sub-study of CTN 222 and CTN 314, and aims to enrol 1,000 participants from those pre-existing cohorts. Study participants will be asked to complete three visits over 18 months as part of the sub-study; these visits will coincide with the scheduled visits for the parent studies (CTN 222 or 314).

During these visits, participants will complete a questionnaire on routine HIV care, emotional and mental wellbeing, satisfaction with virtual care, and COVID-19 symptoms. For participants in CTN 314, an additional tube of blood will be drawn during their visits, while CTN 222 participants will not need to provide additional blood beyond what is regularly collected. This blood will be tested for COVID-19 antibodies. Participants will receive their COVID-19 test results when they become available.

Eligibility Requirements


All people living with HIV/HCV who are enrolled in CTN 222 are eligible to participate in this sub-study. These participants meet the following criteria:

  1. Age >16 years old (i.e., adults, may vary according to provincial criteria)
  2. HIV seropositive
  3. HCV infected or evidence of exposure
  4. Able to provide informed consent

All persons enrolled in CTN 314 are eligible to participate in this sub-study. These participants meet the following criteria:

  1. HIV-1 positive
  2. ≥65 years of age
  3. Able to communicate sufficiently in English or French to consent and complete study procedures

Not Allowed

  1. Not meeting inclusion criteria for CTN 222 or CTN 314


Additional Information

If you would like to take part in this study or want more information, please contact a study coordinator, listed below:

CTN 222 Study Coordinator
Isabelle Robichaud
514-934-1934 ext. 32221

CTN 314 Study Coordinator
Lianne Thai
416-314-4800 ext. 2240

Principal Investigators

Here’s who is leading this study.

Can’t find what you’re looking for? Email ctninfo@hivnet.ubc.ca.

Participating Sites

Here’s where this study is being conducted.

BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital

Vancouver, BC

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Toronto General Hospital, Infectious Disease Division

Toronto, ON

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Research Institute of McGill University Health Centre

Montreal, ON

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